Acid acclimation by Helicobacter pylori.
نویسندگان
چکیده
Helicobacter pylori is a Gram-negative neutralophile associated with peptic ulcers and gastric cancer. It has a unique ability to colonize the human stomach by acid acclimation. It uses the pH-gated urea channel, UreI, to enhance urea access to intrabacterial urease and a membrane-anchored periplasmic carbonic anhydrase to regulate periplasmic pH to approximately 6.1 in acidic media, whereas other neutralophiles cannot regulate periplasmic pH and thus only transit the stomach.
منابع مشابه
Role of the Helicobacter pylori sensor kinase ArsS in protein trafficking and acid acclimation.
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ورودعنوان ژورنال:
- Physiology
دوره 20 شماره
صفحات -
تاریخ انتشار 2005